The 6th Edition of Understanding Pathophysiology is a reader-friendly text, which provides accurate information on treatments, manifestations, and mechanisms of disease across the lifespan, making it an ideal resource for nursing students and professionals. The latest edition includes a new chapter on epigenetics, new content on rare diseases, and separate chapters on male and female reproductive alterations. It also has simplified language, streamlined features, and fully updated information throughout. The book contains more than 1,000 illustrations to depict clinical manifestations and cellular mechanisms underlying diseases. Additionally, the algorithms throughout the text clarify disease progression, while Risk Factor boxes alert readers to important safety considerations associated with specific diseases. Health Alert boxes highlight new developments in biologic research, diagnostic studies, preventive care, treatments, and more, and Quick Check boxes test readers’ retention of important chapter concepts. The Introduction to Pathophysiology in the front matter section provides an introduction to the subject of pathophysiology and explains its importance, while the consistent presentation helps readers better distinguish pathophysiology, clinical manifestations, and evaluation and treatment for each disease.