The fifth edition of Nursing Informatics and the Foundation of Knowledge is an essential textbook that teaches nursing students the fundamental principles of knowledge management and familiarizes them with technology tools and applications. It serves as a practical guide for utilizing modern technology to acquire, process, and share knowledge. The book follows the Foundation of Knowledge Model as an organizational structure for teaching nursing informatics. Updated to reflect the latest advancements in technology, healthcare, and reimbursement services, this edition equips nurses with the necessary tools and knowledge to thrive in the information age. The authors emphasize the significant contributions of informatics to quality improvement, interprofessional collaboration, and the pandemic response. Furthermore, a thought-provoking chapter explores the future impact of technology on patient care, examining topics such as care bots, cyborgs, and artificial intelligence.