This text highlights the benefits of the clear and evidence-based writing and recommendations provided in Primary Care Medicine. Clinicians and students in all primary care disciplines, at any level, can find guidance on a comprehensive range of clinical problems encountered in adult primary care practice. The writing not only provides answers to screening, prevention, evaluation, or management questions but also offers a review of best evidence integrated with considerations of affordability, cost-effectiveness, convenience, and patient preference. The chapters present scientifically validated guidance that allows physicians to go beyond standard consensus guidelines and provide highly personalized care. The importance of team-based approaches of primary care delivery is recognized, and special consideration is given to it to achieve high levels of practice performance. Primary Care Medicine’s digital format and quarterly updates provide current decision support at the point of care. New online resources, including a recommended curriculum for trainees and faculty, and access to state-of-the-art, condition-specific decision grids facilitate patient participation in shared decision-making.